Analysis of flow cytometric aneuploid DNA histograms: validation of an automatic procedure against ad hoc experimental data

In this paper we present an improved version of a method for the automatic analysis of flow cytometric DNA histograms from samples containing a mixture of two cell populations. The procedure is tested against two sets of ad hoc experimental data, obtained by mixing cultures of cell lines in different known proportions. The potentialities of the method are enlightened and discussed with regard to its capability of recovering the population percentages, the DNA index and the G0/G1, S, G2+M phase fractions of each population. On the basis of the obtained results, the procedure appears to be a promising tool in the flow cytometric data analysis and, in particular, in problems of diagnosis and prognosis of tumor diseases

Study of associate production of the Higgs boson in the diphoton decay channel at the CMS experiment

The observation of a boson compatible with the Standard Model (SM) Higgs particle is the starting point for the complete understanding of the electroweak symmetry-breaking mechanism. More specifically, the exact determination of the Higgs couplings to bosons and fermions is crucial to establish if the properties of this particle are compatible with the theoretical predictions. In order to achieve a good sensitivity in couplings measurements it is important to consider those production modes where the Higgs boson is produced in association with W/Z bosons or quarks. The characteristic topology of these events allows to perform an exclusive analysis, crucial for accurate measurements of couplings

Coralline algae in a naturally acidified ecosystem persist by maintaining control of skeletal mineralogy and size

To understand the effects of ocean acidification (OA) on marine calcifiers, the trade-offs among different sublethal responses within individual species and the emergent effects of these trade-offs must be determined in an ecosystem setting. Crustose coralline algae (CCA) provide a model to test the ecological consequences of such sublethal effects as they are important in ecosystem functioning, service provision, carbon cycling and use dissolved inorganic carbon to calcify and photosynthesize. Settlement tiles were placed in ambient pH, low pH and extremely low pH conditions for 14 months at a natural CO2 vent. The size, magnesium (Mg) content and molecular-scale skeletal disorder of CCA patches were assessed at 3.5, 6.5 and 14 months from tile deployment. Despite reductions in their abundance in low pH, the largest CCA from ambient and low pH zones were of similar sizes and had similar Mg content and skeletal disorder. This suggests that the most resilient CCA in low pH did not trade-off skeletal structure to maintain growth. CCA that settled in the extremely low pH, however, were significantly smaller and exhibited altered skeletal mineralogy (high Mg calcite to gypsum (hydrated calcium sulfate)), although at present it is unclear if these mineralogical changes offered any fitness benefits in extreme low pH. This field assessment of biological effects of OA provides endpoint information needed to generate an ecosystem relevant understanding of calcifying system persistence

A superfluid-droplet crystal and a free-space supersolid in a dipole-blockaded gas

A novel supersolid phase is predicted for an ensemble of Rydberg atoms in the dipole-blockade regime, interacting via a repulsive dipolar potential "softened" at short distances. Using exact numerical techniques, we study the low temperature phase diagram of this system, and observe an intriguing phase consisting of a crystal of mesoscopic superfluid droplets. At low temperature, phase coherence throughout the whole system, and the ensuing bulk superfluidity, are established through tunnelling of identical particles between neighbouring droplets.Comment: 4 pages, 4 figure

Strongly correlated gases of Rydberg-dressed atoms: quantum and classical dynamics

We discuss techniques to generate long-range interactions in a gas of groundstate alkali atoms, by weakly admixing excited Rydberg states with laser light. This provides a tool to engineer strongly correlated phases with reduced decoherence from inelastic collisions and spontaneous emission. As an illustration, we discuss the quantum phases of dressed atoms with dipole-dipole interactions confined in a harmonic potential, as relevant to experiments. We show that residual spontaneous emission from the Rydberg state acts as a heating mechanism, leading to a quantum-classical crossover.Comment: 4 pages, 4 figure

Probabilistic learning on graphs via contextual architectures

We propose a novel methodology for representation learning on graph-structured data, in which a stack of Bayesian Networks learns different distributions of a vertex's neighbour- hood. Through an incremental construction policy and layer-wise training, we can build deeper architectures with respect to typical graph convolutional neural networks, with benefits in terms of context spreading between vertices. First, the model learns from graphs via maximum likelihood estimation without using target labels. Then, a supervised readout is applied to the learned graph embeddings to deal with graph classification and vertex classification tasks, showing competitive results against neural models for graphs. The computational complexity is linear in the number of edges, facilitating learning on large scale data sets. By studying how depth affects the performances of our model, we discover that a broader context generally improves performances. In turn, this leads to a critical analysis of some benchmarks used in literature

Quantum Degenerate Systems

Degenerate dynamical systems are characterized by symplectic structures whose rank is not constant throughout phase space. Their phase spaces are divided into causally disconnected, nonoverlapping regions such that there are no classical orbits connecting two different regions. Here the question of whether this classical disconnectedness survives quantization is addressed. Our conclusion is that in irreducible degenerate systems --in which the degeneracy cannot be eliminated by redefining variables in the action--, the disconnectedness is maintained in the quantum theory: there is no quantum tunnelling across degeneracy surfaces. This shows that the degeneracy surfaces are boundaries separating distinct physical systems, not only classically, but in the quantum realm as well. The relevance of this feature for gravitation and Chern-Simons theories in higher dimensions cannot be overstated.Comment: 18 pages, no figure

Instanton traces in lattice gluon correlation functions

Strong coupling constant computed in Landau gauge and MOM renormalization scheme from lattice two and three gluon Green Functions exhibits an unexpected behavior in the deep IR, showing a maximum value around $1 {\rm GeV}$. We analise this coupling below this maximum within a semiclassical approach, were gluon degrees of freedom at very low energies are described in terms of the classical solutions of the lagrangian, namely instantons. We provide some new results concerning the relationship between instantons and the low energy dynamics of QCD, by analising gluon two- and three-point Green functions separately and with the help of a cooling procedure to eliminate short range correlations.Comment: 4 pages, talk given at XXXX Rencontres de Moriond on QCD and Hadronic Interactions, La Thuile (Italy

Modified instanton profile effects from lattice Green functions

We trace here instantons through the analysis of pure Yang-Mills gluon Green functions in the Landau gauge for a window of IR momenta (0.4 GeV $< k < 0.9$ GeV). We present lattice results that can be fitted only after substituting the BPST profile in the Instanton liquid model (ILM) by one based on the Diakonov and Petrov variational methods. This also leads us to gain information on the parameters of ILM.Comment: 32 pagex, 6 figure

What is a Gene? A Two Sided View

The need to account for all currently available experimental observations concerning the gene nature, has reshaped the concept of gene turning it from the essentially mechanistic unit, predominant during the '70s, into a quite abstract open and generalized entity, whose contour appears less defined as compared to the past. Here we propose the essence of the gene to be considered double faced. In this respect genotypic and phenotypic entities of a gene would coexist and mix reciprocally. This harmonizes present knowledge with current definitions and predisposes for remodelling of our thinking as a consequence of future discoveries. A two sided view of the gene also allows to combine the genetic and epigenetic aspects in a unique solution, being structural and functional at the same time and simultaneously able to include the different levels in an overlapping unicum